No matter how secure Windows gets, there's still the little problem of file associations that never seems to get enough attention from Microsoft. If a recent malware infection has left your PC with .exe files that don't run, or .lnk files that don't behave as shortcuts do, then you'll want to head over here for a remedy.
Typically, it's just .exe files but the list of available fixes should be warning enough that other file extensions are equally vulnerable.
Exe files that just won't run
How to remove malware from Windows
Technician's toolbox - malicious software removal tools